Rapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer.

ABSTRACT:

Purpose

Mechanisms mediating androgen receptor (AR) reactivation in prostate cancer that progresses after castration (castration-resistant prostate cancer; CRPC) and subsequent treatment with abiraterone (CYP17A1 inhibitor that further suppresses androgen synthesis) remain unclear.

Experimental design

Prostate cancer xenografts were examined to identify mechanism of progression after castration and abiraterone.

Results

AR reactivation in abiraterone-resistant VCaP xenografts was not associated with restoration of intratumoral androgens or alterations in AR coregulators. In contrast, mRNA encoding full-length AR (AR-FL) and a constitutively active splice variant (AR-V7) were increased compared with xenografts before castration, with an increase in AR-V7 relative to AR-

SUBMITTER: Yu Z 

PROVIDER: S-EPMC4022291 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature