Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy.

ABSTRACT: Diabetic nephropathy (DN) is a progressive fibrotic condition that may lead to end-stage renal disease and kidney failure. Transforming growth factor-β1 and bone morphogenetic protein-7 (BMP7) have been shown to induce DN-like changes in the kidney and protect the kidney from such changes, respectively. Recent data identified insulin action at the level of the nephron as a crucial factor in the development and progression of DN. Insulin requires a family of insulin receptor substrate (IRS) proteins for its physiological effects, and many reports have highlighted the role of insulin and IRS proteins in kidney physiology and disease. Here, we observed IRS2 expression predominantly in the developing and adult kidney epithelium in mouse and human. BMP7 treatment of human kidney proximal tubule

SUBMITTER: Hookham MB 

PROVIDER: S-EPMC4022317 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature