LAPTM4B polymorphism increases susceptibility to multiple cancers in Chinese populations: a meta-analysis.

ABSTRACT:

Background

Lysosome-associated protein transmembrane-4 beta (LAPTM4B) is a novel cancer-related gene. While recent studies have reported that the LAPTM4B polymorphism increased the susceptibility of several cancers, the results remain inconclusive. Therefore, we performed a meta-analysis to systematically summarize the possible association.

Results

The meta-analysis was conducted based on 17 studies in Chinese populations, including 4160 cases and 4148 controls. The relevant studies were searched through electronic databases updated in November 2013. The strength of association between the LAPTM4B polymorphism and susceptibility to multiple cancers was assessed by odds ratio (OR) and 95% confidence interval (95% CI).The meta-analysis results suggested that the LAPTM4B polymo

SUBMITTER: Mo C 

PROVIDER: S-EPMC4022328 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature