Common strength and localization of spontaneous and evoked synaptic vesicle release sites.

ABSTRACT:

Background

Different pools and functions have recently been attributed to spontaneous and evoked vesicle release. Despite the well-established function of evoked release, the neuronal information transmission, the origin as well as the function of spontaneously fusing synaptic vesicles have remained elusive. Recently spontaneous release was found to e.g. regulate postsynaptic protein synthesis or has been linked to depressive disorder. Nevertheless the strength and cellular localization of this release form was neglected so far, which are both essential parameters in neuronal information processing.

Findings

Here we show that the complete recycling pool can be turned over by spontaneous trafficking and that spontaneous fusion rates critically depend on the neuronal localizat

SUBMITTER: Loy K 

PROVIDER: S-EPMC4022376 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature