Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells.

ABSTRACT:

Background

Cellular plasticity confers cancer cells the ability to adapt to microenvironmental changes, a fundamental requirement for tumour progression and metastasis. The epithelial to mesenchymal transition (EMT) is a transcriptional programme associated with increased cell motility and stemness. Besides EMT, the mesenchymal to amoeboid transition (MAT) has been described during tumour progression but to date, little is known about its transcriptional control and involvement in stemness. The aim of this manuscript is to investigate (i) the transcriptional profile associated with the MAT programme and (ii) to study whether MAT acquisition in melanoma cancer cells correlates with clonogenic potential to promote tumour growth.

Results

By using a multidisciplinary approach, w

SUBMITTER: Taddei ML 

PROVIDER: S-EPMC4022383 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature