Intestinal permeability in children/adolescents with functional dyspepsia.

ABSTRACT:

Background

An altered intestinal mucosal barrier has been demonstrated in subsets of patients with IBS and FAP and may be an additional biological factor contributing to symptom generation in children with FD. The objective of this study was to determine if intestinal permeability is increased in children/adolescents with functional dyspepsia (FD) and whether intestinal permeability is correlated with mucosal inflammation and/or symptoms of anxiety or depression in this population.

Methods

A sugar absorption test was performed in 19 patients with FD and 19 controls. Anxiety and depression were assessed in both groups utilizing a standard questionnaire. In FD patients, duodenal mean and peak mast cell and eosinophil densities were determined.

Results

Intestinal permeab

SUBMITTER: Neilan NA 

PROVIDER: S-EPMC4022401 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature