Kallikrein 3 and vitamin D receptor polymorphisms: potentials environmental risk factors for prostate cancer.

ABSTRACT:

Objective

To investigate the relationship and interaction of the single nucleotide polymorphisms (SNPs) of KLK3 and VDR and environmental factors with the predisposition to prostate cancer within Chinese population.

Methods

The comparison between 108 patients and 242 healthy people was carried out by using the TaqMan/MGB Probe Technology to determine the genotypes of KLK3(rs2735839 is located between KLK2 and KLK3) and VDR (rs731236 is located exon 9). Univariate and multivariate logistic regression model were used to assess the connection of genetic polymorphisms and environmental risk factors with PCa by collecting demographic information, as well as BMI, consumption of cigarettes, alcohol, and tea, exercise, and other environmental risk factors.

Results

The appeari

SUBMITTER: Hu J 

PROVIDER: S-EPMC4022449 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature