Spermatid cyst polarization in Drosophila depends upon apkc and the CPEB family translational regulator orb2.

ABSTRACT: Mature Drosophila sperm are highly polarized cells--on one side is a nearly 2 mm long flagellar tail that comprises most of the cell, while on the other is the sperm head, which carries the gamete's genetic information. The polarization of the sperm cells commences after meiosis is complete and the 64-cell spermatid cyst begins the process of differentiation. The spermatid nuclei cluster to one side of the cyst, while the flagellar axonemes grows from the other. The elongating spermatid bundles are also polarized with respect to the main axis of the testis; the sperm heads are always oriented basally, while the growing tails extend apically. This orientation within the testes is important for transferring the mature sperm into the seminal vesicles. We show here that orienting cyst polariza

SUBMITTER: Xu S 

PROVIDER: S-EPMC4022466 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature