Insights into the genetic structure and diversity of 38 South Asian Indians from deep whole-genome sequencing.

ABSTRACT: South Asia possesses a significant amount of genetic diversity due to considerable intergroup differences in culture and language. There have been numerous reports on the genetic structure of Asian Indians, although these have mostly relied on genotyping microarrays or targeted sequencing of the mitochondria and Y chromosomes. Asian Indians in Singapore are primarily descendants of immigrants from Dravidian-language-speaking states in south India, and 38 individuals from the general population underwent deep whole-genome sequencing with a target coverage of 30X as part of the Singapore Sequencing Indian Project (SSIP). The genetic structure and diversity of these samples were compared against samples from the Singapore Sequencing Malay Project and populations in Phase 1 of the 1,000 Genome

SUBMITTER: Wong LP 

PROVIDER: S-EPMC4022468 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature