G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity.

ABSTRACT: Dietary restriction (DR) is the most consistent means of extending longevity in a wide range of organisms. A growing body of literature indicates that mitochondria play an important role in longevity extension by DR, but the impact of mitochondrial genotypes on the DR process have received little attention. Mitochondrial function requires proper integration of gene products from their own genomes (mtDNA) and the nuclear genome as well as the metabolic state of the cell, which is heavily influenced by diet. These three-way mitochondrial-nuclear-dietary interactions influence cellular and organismal functions that affect fitness, aging, and disease in nature. To examine these interactions in the context of longevity, we generated 18 "mito-nuclear" genotypes by placing mtDNA from strains of D

SUBMITTER: Zhu CT 

PROVIDER: S-EPMC4022469 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature