INsPECT, an open-source and versatile software for automated quantification of (Leishmania) intracellular parasites.

ABSTRACT: Intracellular protozoan parasites are causative agents of infectious diseases that constitute major health problems for developing countries. Leishmania sp., Trypanosoma cruzi or Toxoplasma gondii are all obligate intracellular protozoan parasites that reside and multiply within the host cells of mammals, including humans. Following up intracellular parasite proliferation is therefore an essential and a quotidian task for many laboratories working on primary screening of new natural and synthetic drugs, analyzing drug susceptibility or comparing virulence properties of natural and genetically modified strains. Nevertheless, laborious manual microscopic counting of intracellular parasites is still the most commonly used approach. Here, we present INsPECT (Intracellular ParasitE CounTer), an

SUBMITTER: Yazdanparast E 

PROVIDER: S-EPMC4022486 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature