Anti-aging effect of adipose-derived stem cells in a mouse model of skin aging induced by D-galactose.

ABSTRACT:

Introduction

Glycation products accumulate during aging of slowly renewing tissue, including skin, and are suggested as an important mechanism underlying the skin aging process. Adipose-derived cells are widely used in the clinic to treat ischemic diseases and enhance wound healing. Interestingly, adipose-derived stem cells (ASCs) are also effective in anti-aging therapy, although the mechanism underlying their effects remains unknown. The purpose of the present study was to examine the anti-aging effect of ASCs in a D-galactose-induced aging animal model and to clarify the underlying mechanism.

Materials and methods

Six-week-old nude mice were subcutaneously injected with D-gal daily for 8 weeks. Two weeks after completion of treatment, mice were randomized to receive subcu

SUBMITTER: Zhang S 

PROVIDER: S-EPMC4022592 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature