Unidirectional photoreceptor-to-Muller glia coupling and unique K+ channel expression in Caiman retina.

ABSTRACT:

Background

Müller cells, the principal glial cells of the vertebrate retina, are fundamental for the maintenance and function of neuronal cells. In most vertebrates, including humans, Müller cells abundantly express Kir4.1 inwardly rectifying potassium channels responsible for hyperpolarized membrane potential and for various vital functions such as potassium buffering and glutamate clearance; inter-species differences in Kir4.1 expression were, however, observed. Localization and function of potassium channels in Müller cells from the retina of crocodiles remain, hitherto, unknown.

Methods

We studied retinae of the Spectacled caiman (Caiman crocodilus fuscus), endowed with both diurnal and nocturnal vision, by (i) immunohistochemistry, (ii) whole-cell voltage-clamp, and (ii

SUBMITTER: Zayas-Santiago A 

PROVIDER: S-EPMC4022631 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature