Global gene expression shift during the transition from early neural development to late neuronal differentiation in Drosophila melanogaster.

ABSTRACT: Regulation of transcription is one of the mechanisms involved in animal development, directing changes in patterning and cell fate specification. Large temporal data series, based on microarrays across the life cycle of the fly Drosophila melanogaster, revealed the existence of groups of genes which expression increases or decreases temporally correlated during the life cycle. These groups of genes are enriched in different biological functions. Here, instead of searching for temporal coincidence in gene expression using the entire genome expression data, we searched for temporal coincidence in gene expression only within predefined catalogues of functionally related genes and investigated whether a catalogue's expression profile can be used to generate larger catalogues, enriched in genes

SUBMITTER: Cantera R 

PROVIDER: S-EPMC4022633 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature