Genistein promotes endothelial colony-forming cell (ECFC) bioactivities and cardiac regeneration in myocardial infarction.

ABSTRACT:

Unlabelled

Although stem cell-mediated treatment of ischemic diseases offers significant therapeutic promise, the limitation in the therapeutic efficacy of transplanted stem cells in vivo because of poor engraftment remains a challenge. Several strategies aimed at improving survival and engraftment of stem cells in the ischemic myocardium have been developed, such as cell transplantation in combination with growth factor delivery, genetic modification of stem cells, and/or cell therapy using scaffolds. To improve therapeutic efficacy, we investigated the effects of genistein on the engraftment of transplanted ECFCs in an acute myocardial ischemia model.

Results

We found that genistein treatment enhanced ECFCs' migration and proliferation, which was accompanied by increases i

SUBMITTER: Lee SH 

PROVIDER: S-EPMC4022670 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature