Neuropeptide Y receptor gene expression in the primate amygdala predicts anxious temperament and brain metabolism.

ABSTRACT:

Background

Anxious temperament (AT) is identifiable early in life and predicts the later development of anxiety disorders and depression. Neuropeptide Y (NPY) is a putative endogenous anxiolytic neurotransmitter that adaptively regulates responses to stress and might confer resilience to stress-related psychopathology. With a well-validated nonhuman primate model of AT, we examined expression of the NPY system in the central nucleus (Ce) of the amygdala, a critical neural substrate for extreme anxiety.

Methods

In 24 young rhesus monkeys, we measured Ce messenger RNA (mRNA) levels of all members of the NPY system that are detectable in the Ce with quantitative real time polymerase chain reaction. We then examined the relationship between these mRNA levels and both AT expressi

SUBMITTER: Roseboom PH 

PROVIDER: S-EPMC4022724 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature