Dopaminergic contributions to hippocampal pathophysiology in schizophrenia: a computational study.

ABSTRACT: Since the original formulation of the dopamine hypothesis, a number of other cellular-level abnormalities--eg, NMDA receptor hypofunction, GABA system dysfunction, neural connectivity disturbances--have been identified in schizophrenia, but the manner in which these potentially interact with hyperdopaminergia to lead to schizophrenic symptomatology remains uncertain. Previously, we created a neuroanatomically detailed, biophysically realistic computational model of hippocampus in the control (unaffected) and schizophrenic conditions, implemented on a 72-processor supercomputer platform. In the current study, we apply the effects of dopamine (DA), dose-dependently, to both models on the basis of an exhaustive review of the neurophysiologic literature on DA's ion channel and synaptic level e

SUBMITTER: Siekmeier PJ 

PROVIDER: S-EPMC4023145 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature