The interplay of DNA methylation over time with Th2 pathway genetic variants on asthma risk and temporal asthma transition.

ABSTRACT:

Background

Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation in genes in this pathway (IL4, IL4R, IL13, GATA3, and STAT6) influence asthma risk, that such influences are age-dependent, and that methylation of some CpG sites changes over time in accordance with asthma transition. We tested these hypotheses in subsamples of girls from a population-based birth cohort established on the Isle of Wight, UK, in 1989.

Results

Logistic regression models were applied to test the interaction effect of DNA methylation and SNP on asthma within each of the five genes. Bootstrapping was used to assess the models identified. From 1,361 m

SUBMITTER: Zhang H 

PROVIDER: S-EPMC4023182 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature