Genome-wide patterns of identity-by-descent sharing in the French Canadian founder population.

ABSTRACT: In genetics the ability to accurately describe the familial relationships among a group of individuals can be very useful. Recent statistical tools succeeded in assessing the degree of relatedness up to 6-7 generations with good power using dense genome-wide single-nucleotide polymorphism data to estimate the extent of identity-by-descent (IBD) sharing. It is therefore important to describe genome-wide patterns of IBD sharing for more remote and complex relatedness between individuals, such as that observed in a founder population like Quebec, Canada. Taking advantage of the extended genealogical records of the French Canadian founder population, we first compared different tools to identify regions of IBD in order to best describe genome-wide IBD sharing and its correlation with genealogi

SUBMITTER: Gauvin H 

PROVIDER: S-EPMC4023206 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature