Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes.

ABSTRACT: Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one method by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can interfere with bacterial adhesion or the chemical reactions used for quorum sensing are therefore a potential means to control bacterial population responses. Here, we report how polymeric 'bacteria sequestrants', designed to bind to bacteria through electrostatic interactions and therefore inhibit bacterial adhesion to surfaces, induce the expression of quorum-sensing-controlled phenotypes as a consequence of cell clustering. A combination of polymer and analytical chemistry, biological assays and computational modelling has been used to ch

SUBMITTER: Lui LT 

PROVIDER: S-EPMC4023227 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature