Chemotherapy and its evolving role in the management of advanced prostate cancer.

ABSTRACT: Advanced prostate cancer has been recognized as being responsive to androgen deprivation since the 1940s when Charles Huggins first described the role of surgical castration in managing these patients. However, androgen deprivation only results in transient disease control for the vast majority of men, with those progressing in spite of castrate testosterone levels labeled as having castrate-resistant prostate cancer (CRPC). Until 2004, the therapeutic arena for these patients had remained stagnant, with no agent having shown a survival gain in the CRPC setting. Two landmark publications changed the prostate cancer treatment landscape by providing 'level-1 evidence' that docetaxel-based chemotherapy led to prolongation in overall survival (OS). This was followed by the approval of cabazita

SUBMITTER: Schweizer MT 

PROVIDER: S-EPMC4023356 | biostudies-literature | 2014 May-Jun

REPOSITORIES: biostudies-literature