An overlapping set of genes is regulated by both NFIB and the glucocorticoid receptor during lung maturation.

ABSTRACT:

Background

Lung maturation is a late fetal developmental event in both mice and humans. Because of this, lung immaturity is a serious problem in premature infants. Disruption of genes for either the glucocorticoid receptor (Nr3c1) or the NFIB transcription factors results in perinatal lethality due to lung immaturity. In both knockouts, the phenotype includes excess cell proliferation, failure of saccularization and reduced expression of markers of epithelial differentiation. This similarity suggests that the two genes may co-regulate a specific set of genes essential for lung maturation.

Results

We analyzed the roles of these two transcription factors in regulating transcription using ChIP-seq data for NFIB, and RNA expression data and motif analysis for both. Our new ChIP-

SUBMITTER: Lajoie M 

PROVIDER: S-EPMC4023408 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature