The Role of Oral Pathobionts in Dysbiosis during Periodontitis Development.

ABSTRACT: An emerging concept is the tight relationship between dysbiosis (microbiota imbalance) and disease. The increase in knowledge about alterations in microbial communities that reside within the host has made a strong impact not only on dental science, but also on immunology and microbiology as well as on our understanding of several diseases. Periodontitis is a well-characterized human disease associated with dysbiosis, characterized by the accumulation of multiple bacteria that play individual and critical roles in bone loss around the teeth. Dysbiosis is largely dependent on cooperative and competitive interactions among oral microbes during the formation of the pathogenic biofilm community at gingival sites. Oral pathobionts play different and synergistic roles in periodontitis developmen

SUBMITTER: Jiao Y 

PROVIDER: S-EPMC4023464 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature