Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the diabetes prevention program.

ABSTRACT:

Objective

To assess associations and genotype × treatment interactions for melanocortin 4 receptor (MC4R) locus variants and obesity-related traits.

Design and methods

Diabetes prevention program (DPP) participants (N = 3,819, of whom 3,356 were genotyped for baseline and 3,234 for longitudinal analyses) were randomized into intensive lifestyle modification (diet, exercise, weight loss), metformin or placebo control. Adiposity was assessed in a subgroup (n = 909) using computed tomography. All analyses were adjusted for age, sex, ethnicity and treatment.

Results

The rs1943218 minor allele was nominally associated with short-term (6 month; P = 0.032) and long-term (2 year; P = 0.038) weight change. Eight SNPs modified response to treatment on short-term (rs17066856, rs

SUBMITTER: Pan Q 

PROVIDER: S-EPMC4023472 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature