Adiponectin gene variants, adiponectin isoforms and cardiometabolic risk in type 2 diabetic patients.

ABSTRACT:

Aims/introduction

The aim of the present study was to examine the associations of rs2241766 (+45T>G), rs1501299 (+276G>T), rs17300539 (-11391G>A) and rs182052 (-10069G>A) in the adiponectin (Ad) gene with adiponectin concentrations, and concomitantly the association of these variants with cardiometabolic risk in type 2 diabetic patients of African ancestry.

Materials and methods

A cross-sectional study of 200 patients was carried out. Concentrations of total, high (HMW), middle (MMW) and low (LMW) molecular weight adiponectin isoforms were measured. The four polymorphisms were genotyped.

Results

Decreased values were noted for total Ad in overweight, dyslipidemia and coronary artery disease (CAD), for HMW in overweight and dyslipidemia, for MMW in CAD, for LMW in dysl

SUBMITTER: Foucan L 

PROVIDER: S-EPMC4023583 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature