Obesity as an effect modifier of the association between leptin and diabetic kidney disease.

ABSTRACT:

Aims/introduction

Obesity has been shown to be a modifier of the association between leptin levels and cardiovascular events. We examined whether obesity modifies the association between serum leptin levels and the progression of diabetic kidney disease.

Materials and methods

This was an observational longitudinal study on patients with type 2 diabetes. We enrolled 410 and 348 patients in the eGFR and ACR cohorts, respectively. Patients were classified into three groups by sex-specific tertile of leptin levels. Obesity was defined as body mass index ≥25 kg/m(2). Outcomes were the rate of change in estimated glomerular filtration rate (eGFR) and progression to a more advanced stage of albuminuria.

Results

In the eGFR cohort, the mean eGFR change during the median follo

SUBMITTER: Hanai K 

PROVIDER: S-EPMC4023586 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature