MKL1/2 and ELK4 co-regulate distinct serum response factor (SRF) transcription programs in macrophages.

ABSTRACT:

Background

Serum response factor (SRF) is a widely expressed transcription factor involved in multiple regulatory programs. It is believed that SRF can toggle between disparate programs of gene expression through association with different cofactors. However, the direct evidence as to how these factors function on a genome-wide level is still lacking.

Results

In the present study, I explored the functions of SRF and its representative cofactors, megakaryoblastic leukemia 1/2 (MKL1/2) and ETS-domain protein 4 (ELK4), during fungal infection challenge in macrophages. The knockdown study, combined with gene expression array analysis, revealed that MKL1/2 regulated SRF-dependent genes were related to actin cytoskeleton organization, while ELK4 regulated SRF-dependent genes were

SUBMITTER: Xie L 

PROVIDER: S-EPMC4023608 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature