Learning and generalization in schizophrenia: effects of disease and antipsychotic drug treatment.

ABSTRACT:

Background

Schizophrenia involves alterations in hippocampal function. The implications of these alterations for memory function in the illness remain poorly understood. Furthermore, it remains unknown how memory is impacted by drug treatments for schizophrenia. The goal of this study was to delineate specific memory processes that are disrupted in schizophrenia and explore how they are affected by medication. We specifically focus on memory generalization--the ability to flexibly generalize memories in novel situations.

Methods

Individuals with schizophrenia (n = 56) and healthy control subjects (n = 20) were tested on a computerized memory generalization paradigm. Participants first engaged in trial-by-error associative learning. They were then asked to generalize what the

SUBMITTER: Shohamy D 

PROVIDER: S-EPMC4023678 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature