Breast cancer susceptibility loci in association with age at menarche, age at natural menopause and the reproductive lifespan.

ABSTRACT:

Background

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with breast cancer risk. Some of these loci have unknown functional significance and may mediate the effects of hormonal exposures on breast cancer risk. We examined relationships between breast cancer susceptibility variants and menstrual/reproductive factors using data from two population-based studies.

Methods

The first analysis was based on a sample of 1328 women age 20-74 who participated as controls in a case-control study of breast cancer conducted in three U.S. states. We evaluated the associations between age at menarche, age at natural menopause and the reproductive lifespan with 13 previously identified breast cancer variants. Associations were also examine

SUBMITTER: Warren Andersen S 

PROVIDER: S-EPMC4023814 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature