Prospective CT screening for lung cancer in a high-risk population: HIV-positive smokers.

ABSTRACT:

Background

Epidemiological evidence suggests that HIV-infected individuals are at increased risk of lung cancer, but no data exist because large computed tomography (CT) screening trials routinely exclude HIV-infected participants.

Methods

From 2006 to 2013, we conducted the world's first lung cancer screening trial of 224 HIV-infected current/former smokers to assess the CT detection rates of lung cancer. We also used 130 HIV-infected patients with known lung cancer to determine radiographic markers of lung cancer risk using multivariate analysis.

Results

Median age was 48 years with 34 pack-years smoked. During 678 person-years, one lung cancer was found on incident screening. Besides this lung cancer case, 18 deaths (8%) occurred, but none were cancer related. Ther

SUBMITTER: Hulbert A 

PROVIDER: S-EPMC4023914 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature