Dopamine genetic risk score predicts depressive symptoms in healthy adults and adults with depression.

ABSTRACT:

Background

Depression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the pathophysiology of depression, evidence linking dopamine-related genes to depression has been mixed. The current study sought to address this knowledge-gap by examining whether the combined effect of dopamine polymorphisms was associated with depressive symptomatology in both healthy individuals and individuals with depression.

Methods

Data were drawn from three independent samples: (1) a discovery sample of healthy adult participants (n = 273); (2) a replication sample of adults with depression (n = 1,267); and (3) a replication sample of healthy adult participa

SUBMITTER: Pearson-Fuhrhop KM 

PROVIDER: S-EPMC4023941 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature