A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations.

ABSTRACT:

Background

It is well known that the development of cancer is caused by the accumulation of somatic mutations within the genome. For oncogenes specifically, current research suggests that there is a small set of "driver" mutations that are primarily responsible for tumorigenesis. Further, due to recent pharmacological successes in treating these driver mutations and their resulting tumors, a variety of approaches have been developed to identify potential driver mutations using methods such as machine learning and mutational clustering. We propose a novel methodology that increases our power to identify mutational clusters by taking into account protein tertiary structure via a graph theoretical approach.

Results

We have designed and implemented GraphPAC (Graph Protein Amino

SUBMITTER: Ryslik GA 

PROVIDER: S-EPMC4024121 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature