Post-liver transplantation sarcopenia in cirrhosis: a prospective evaluation.

ABSTRACT:

Background and aim

Pre-transplant sarcopenia (reduced skeletal muscle mass) predicts poor outcome in cirrhosis. In contrast, whether muscle mass increases post-orthotopic liver transplantation (OLT) is not known and was studied prospectively.

Methods

Consecutive patients who underwent a comprehensive nutritional evaluation in a liver transplant nutrition clinic were included. Core abdominal muscle area was measured on abdominal computed tomography obtained pre- and post-OLT. Age- and gender-based controls were used to define sarcopenia. Measures of body composition pre-transplant were correlated with computed tomography measurements. Predictors and clinical impact of post-OLT change in muscle area were examined. In three subjects post-OLT and three controls, expression of ge

SUBMITTER: Tsien C 

PROVIDER: S-EPMC4024321 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature