FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression.

ABSTRACT:

Purpose

The transcription factor Forkhead box protein M1 (FOXM1) plays critical roles in cancer development and progression. However, the regulatory role and underlying mechanisms of FOXM1 in cancer metabolism are unknown. In this study, we characterized the regulation of aerobic glycolysis by FOXM1 and its impact on pancreatic cancer metabolism.

Experimental design

The effect of altered expression of FOXM1 on expression of glycolytic enzymes and tumor development and progression was examined using animal models of pancreatic cancer. Also, the underlying mechanisms of altered pancreatic cancer glycolysis were analyzed using in vitro molecular biology. The clinical relevance of aberrant metabolism caused by dysregulated FOXM1 signaling was determined using pancreatic tumor an

SUBMITTER: Cui J 

PROVIDER: S-EPMC4024335 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature