Comparative efficacy and safety of treatments for localised prostate cancer: an application of network meta-analysis.

ABSTRACT:

Context

There is ongoing uncertainty about the optimal management of patients with localised prostate cancer.

Objective

To evaluate the comparative efficacy and safety of different treatments for patients with localised prostate cancer.

Design

Systematic review with Bayesian network meta-analysis to estimate comparative ORs, and a score (0-100%) that, for a given outcome, reflects average rank order of superiority of each treatment compared against all others, using the Surface Under the Cumulative RAnking curve (SUCRA) statistic.

Data sources

Electronic searches of MEDLINE without language restriction.

Study selection

Randomised trials comparing the efficacy and safety of different primary treatments (48 papers from 21 randomised trials included 7350 me

SUBMITTER: Xiong T 

PROVIDER: S-EPMC4024605 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature