Kir6.2 E23K polymorphism is related to secondary failure of sulfonylureas in non-obese patients with type 2 diabetes.

ABSTRACT:

Aims/introduction

The Kir6.2 E23K polymorphism was studied with a special reference to secondary sulfonylurea (SU) failure in non-obese patients with type 2 diabetes.

Materials and methods

We recruited 278 non-obese (body mass index ≤30.0 kg/m(2)) Japanese patients with type 2 diabetes who had a history of SU treatment (for 11.2 ± 6.3 years) and compared the frequency of the secondary SU failure among the genotypes of the polymorphism. Genotyping of the Kir6.2 E23K was carried out by polymerase chain reaction-restriction fragment length polymorphism.

Results

The genotype frequencies of the polymorphism were similar to those previously reported in Japanese patients with type 2 diabetes. The frequency with which patients deteriorated into secondary SU failure was signif

SUBMITTER: Shimajiri Y 

PROVIDER: S-EPMC4025112 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature