In vitro and in silico antidiabetic activity of pyran ester derivative isolated from Tragia cannabina.

ABSTRACT:

Objective

To investigate the in vitro antidiabetic effects of isolated 4-Oxo-4H-pyran-2,6-dicarboxylic acid bis-[6-methyl-heptyl] ester from the chloroform extract of root of Tragia cannabina (T. cannabina) and AMP kinase activation property of the isolated compound.

Methods

The roots of T. cannabina were collected and extracted with ethanol [95% v/v] then chromatographed over silica gel 60-120 mesh of column length 100 cm and diameter 3 cm. Elution was carried out with solvents and solvent mixtures of increasing polarities. Then the chloroform extract was used for isolation. In vitro antidiabetic activity was performed with fertile eggs of White Leghorn chicks by induction of diabetes by streptozotocin.

Results

The isolated pyran ester binds very efficiently within t

SUBMITTER: Sivajothi V 

PROVIDER: S-EPMC4025294 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature