Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis.

ABSTRACT:

Objective

To assess whether corticosteroids are associated with increased risk of gastrointestinal bleeding or perforation.

Design

Systematic review and meta-analysis of randomised, double-blind, controlled trials comparing a corticosteroid to placebo for any medical condition or in healthy participants. Studies with steroids given either locally, as a single dose, or in crossover studies were excluded.

Data sources

Literature search using MEDLINE, EMBASE and Cochrane Database of Systematic Reviews between 1983 and 22 May 2013.

Outcome measure

Outcome measures were the occurrence of gastrointestinal bleeding or perforation. Predefined subgroup analyses were carried out for disease severity, use of non-steroidal anti-inflammatory drugs (NSAIDs) or gastroprotecti

SUBMITTER: Narum S 

PROVIDER: S-EPMC4025450 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature