Coordinated metabolic transitions during Drosophila embryogenesis and the onset of aerobic glycolysis.

ABSTRACT: Rapidly proliferating cells such as cancer cells and embryonic stem cells rely on a specialized metabolic program known as aerobic glycolysis, which supports biomass production from carbohydrates. The fruit fly Drosophila melanogaster also utilizes aerobic glycolysis to support the rapid growth that occurs during larval development. Here we use singular value decomposition analysis of modENCODE RNA-seq data combined with GC-MS-based metabolomic analysis to analyze the changes in gene expression and metabolism that occur during Drosophila embryogenesis, spanning the onset of aerobic glycolysis. Unexpectedly, we find that the most common pattern of co-expressed genes in embryos includes the global switch to glycolytic gene expression that occurs midway through embryogenesis. In contrast to t

SUBMITTER: Tennessen JM 

PROVIDER: S-EPMC4025483 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature