Genomics of CpG methylation in developing and developed zebrafish.

ABSTRACT: DNA methylation is a dynamic process through which specific chromatin modifications can be stably transmitted from parent to daughter cells. A large body of work has suggested that DNA methylation influences gene expression by silencing gene promoters. However, these conclusions were drawn from data focused mostly on promoter regions. Regarding the entire genome, it is unclear how methylation and gene transcription patterns are related during vertebrate development. To identify the genome-wide distribution of CpG methylation, we created series of high-resolution methylome maps of Danio rerio embryos during development and in mature, differentiated tissues. We found that embryonic and terminal tissues have unique methylation signatures in CpG islands and repetitive sequences. Fully differen

SUBMITTER: McGaughey DM 

PROVIDER: S-EPMC4025485 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature