Effects of sample selection bias on the accuracy of population structure and ancestry inference.

ABSTRACT: Population stratification is an important task in genetic analyses. It provides information about the ancestry of individuals and can be an important confounder in genome-wide association studies. Public genotyping projects have made a large number of datasets available for study. However, practical constraints dictate that of a geographical/ethnic population, only a small number of individuals are genotyped. The resulting data are a sample from the entire population. If the distribution of sample sizes is not representative of the populations being sampled, the accuracy of population stratification analyses of the data could be affected. We attempt to understand the effect of biased sampling on the accuracy of population structure analysis and individual ancestry recovery. We examined two

SUBMITTER: Shringarpure S 

PROVIDER: S-EPMC4025489 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature