Does diisocyanate exposure result in neurotoxicity?

ABSTRACT:

Context

Diisocyanates have been associated with respiratory and dermal sensitization. Limited number of case reports, and a few case studies, media, and other references suggest potential neurotoxic effects from exposures to toluene diisocyanate (TDI), 1,6 hexamethylene diisocyanate (HDI), and methylene diisocyanate (MDI). However, a systematic review of the literature evaluating the causal association on humans does not exist to support this alleged association.

Objective

To perform systematic review examining the body of epidemiologic evidence and provide assessment of causal association based on principles of the Sir Austin Bradford Hill criteria or considerations for causal analysis.

Methods

A comprehensive search of public databases for published abstracts, case

SUBMITTER: Hughes MA 

PROVIDER: S-EPMC4025582 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature