Circadian abnormalities in a mouse model of high trait anxiety and depression.

ABSTRACT:

Introduction

Dysregulation of circadian rhythms is a key symptom of mood disorders, including anxiety disorders and depression. Whether the circadian abnormalities observed in depressed patients are cause or consequence of the disease remains elusive. Here we aimed to explore potential disturbances of circadian rhythms in a validated genetic animal model of high trait anxiety and co-morbid depression and examine its molecular correlates.

Materials and methods

Mice selectively bred for high (HAB) and normal (NAB) anxiety- and co-segregating depression-like behavior were subjected to analysis of circadian wheel-running activity to determine light-entrained (LD) and free-running circadian (DD) rhythms and a light-induced phase shift. Clock gene expression in HAB/NAB hippocampal

SUBMITTER: Griesauer I 

PROVIDER: S-EPMC4025598 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature