Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice.

ABSTRACT:

Aim

The present study was conducted to define the relationship between the anti-aging effect of ubiquinol-10 supplementation and mitochondrial activation in senescence-accelerated mouse prone 1 (SAMP1) mice.

Results

Here, we report that dietary supplementation with ubiquinol-10 prevents age-related decreases in the expression of sirtuin gene family members, which results in the activation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a major factor that controls mitochondrial biogenesis and respiration, as well as superoxide dismutase 2 (SOD2) and isocitrate dehydrogenase 2 (IDH2), which are major mitochondrial antioxidant enzymes. Ubiquinol-10 supplementation can also increase mitochondrial complex I activity and decrease levels of oxidative stres

SUBMITTER: Tian G 

PROVIDER: S-EPMC4025630 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature