Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.

ABSTRACT: In this paper we describe a series of 3-cyano-5-aryl-7-aminopyrazolo[1,5-a]pyrimidine hits identified by kinase-focused subset screening as starting points for the structure-based design of conformationally constrained 6-acetamido-indole inhibitors of CK2. The synthesis, SAR, and effects of this novel series on Akt signaling and cell proliferation in vitro are described.

SUBMITTER: Dowling JE 

PROVIDER: S-EPMC4025639 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature