Lipidated peptidomimetics with improved antimicrobial activity.

ABSTRACT: We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.

SUBMITTER: Hu Y 

PROVIDER: S-EPMC4025737 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature