Water-soluble progesterone analogues are effective, injectable treatments in animal models of traumatic brain injury.

ABSTRACT: After more than 30 years of research and 30 failed clinical trials with as many different treatments, progesterone is the first agent to demonstrate robust clinical efficacy as a treatment for traumatic brain injuries. It is currently being investigated in two, independent phase III clinical trials in hospital settings; however, it presents a formidable solubility challenge that has so far prevented the identification of a formulation that would be suitable for emergency field response use or battlefield situations. Accordingly, we have designed and tested a novel series of water-soluble analogues that address this critical need. We report here the synthesis of C-20 oxime conjugates of progesterone as therapeutic agents for traumatic brain injuries with comparable efficacy in animal models

SUBMITTER: Guthrie DB 

PROVIDER: S-EPMC4025794 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature