Resting brain perfusion and selected vascular risk factors in healthy elderly subjects.

ABSTRACT:

Background and purpose

Both cerebral hypoperfusion and vascular risk factors have been implicated in early aging of the brain and the development of neurodegenerative disease. However, the current knowledge of the importance of cardiovascular health on resting brain perfusion is limited. The aim of the present study was to elucidate the relation between brain perfusion variability and risk factors of endothelial dysfunction and atherosclerosis in healthy aged subjects.

Methods

Thirty-eight healthy subjects aged 50-75 years old were included. Mean global brain perfusion was measured using magnetic resonance phase contrast mapping and regional brain perfusion by use of arterial spin labeling.

Results

Mean global brain perfusion was inversely correlated with caffeine and

SUBMITTER: Henriksen OM 

PROVIDER: S-EPMC4026139 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature