Serum antioxidant nutrients, vitamin A, and mortality in U.S. Adults.

ABSTRACT:

Background

Observational studies have suggested that antioxidant nutrients may reduce cancer and overall mortality risks. However, most randomized trials have failed to show survival benefits. Examining nonlinear associations between antioxidant levels and health outcomes may help to explain these discrepant findings.

Methods

We evaluated all-cause, cancer, and cardiovascular mortality risks associated with quintiles (Q1-Q5) of serum antioxidant (vitamins C and E, β-carotene, and selenium) and vitamin A levels, in 16,008 adult participants of The Third National Health and Nutrition Examination Survey (NHANES III; 1988-1994).

Results

Over a median follow-up period of 14.2 years, there were 4,225 deaths, including 891 from cancer and 1,891 from cardiovascular disease. W

SUBMITTER: Goyal A 

PROVIDER: S-EPMC4026170 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature