CaMKK-CaMK1a, a new post-traumatic signalling pathway induced in mouse somatosensory neurons.

ABSTRACT: Neurons innervating peripheral tissues display complex responses to peripheral nerve injury. These include the activation and suppression of a variety of signalling pathways that together influence regenerative growth and result in more or less successful functional recovery. However, these responses can be offset by pathological consequences including neuropathic pain. Calcium signalling plays a major role in the different steps occurring after nerve damage. As part of our studies to unravel the roles of injury-induced molecular changes in dorsal root ganglia (DRG) neurons during their regeneration, we show that the calcium calmodulin kinase CaMK1a is markedly induced in mouse DRG neurons in several models of mechanical peripheral nerve injury, but not by inflammation. Intrathecal injecti

SUBMITTER: Elziere L 

PROVIDER: S-EPMC4026325 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature